I choose to be optimistic.
Flashback to the Valencia-game: 90 minutes played, we are loosing important points, but gets a penalty. Messi (who has been debated as penalty-taker and isn't the most effective from the spot) versus the best penalty-saving keeper in the world (with a freakish 50/50 save-percentage). Messi scores and breaks the spell.
The statistics and odds couldn't have been set up worse, but in the end it didn't matter: Therefore it is not written in stone that we will lose at Anoeta either, a win is most certainly possible.