This is Barca, I expect a strong lineup for every game of the year except for Copa round of 32, Copa Catalunya, and CL group games after Barca has clinched 1st. Why would any true cule ever advocate picking lineups that are not strong?
I would expect about as many rotations as there were for the Villarreal game. If Umtitti is fit, Pique should rest. It's also time for Busquets and Messi to rest. I doubt Messi will be willing to do that, but he should. He can come in as a sub.
I bet that when new managers get hired, they interview with Messi. Messi makes it clear that if you want to be Barca manager, Messi must start at least 95% of the games, and almost never be subbed. It will be interesting to see if Messi continues to play so much as he gets into his 30s.