Wonder if this would work. Doubt it (3-4-3 already failed with Pep), but it would be interesting:
Mats
Pique-CB-Alba
Busquets
Xavi/Rakitic-Iniesta
---------Messi--------
Sanchez-Suarez-Neymar
Kinda like what we used against Milan, with Sanchez playing a similar role to Alves's.