The midfield battle will be a good parameter of any progress we've made in game management, something we lacked at times last season. Ronaldo looks terrible right now, Messi being injured has done more for Barça than Ronaldo has for Madrid so far. Sure, they are going to try and turn up and we are going to miss Messi and I'd argue more Rakitic's abscence a lot but I'm not convinced at all of Benitez's setup so far. With how ragged their left side was run by Sevilla last weekend and the injuries they have, I don't see them keeping a clean sheet. Benitez organizes his teams not to concede but their offense looks lost without Benzema. When I read back in July that Benitez was going to try Ronaldo as a 9, I knew they were going to run into this problem with link-up. He's recently tried Bale there now and he hasn't a clue and Ronaldo just runs and I'm sure the concept of playing with his back to the goal just seems like Thai to him.
Last year, Madrid went unbeaten through January and Ancelotti's team were much more dynamic and fluid offensively and solid defensively. We played a much stronger team in both legs and in the first leg, it was Suarez's first game with the team.
As far as midfield being overrun, it won't be as noticeable as say the 2-1 at the Camp Nou because their offense looks so blunted with Benitez's tinkerings and the Benz investigation (which is a shame). Busi and Iniesta have looked really good recently, so between them I'd say them and Modric and Kroos cancel out. Isco/James vs. Roberto is clear on paper but Roberto is scrappy and that's a good characteristic to have in these types of matches so he can at least do a job, keep either Isco/James quiet with Busi and let Iniesta have space to attack and roam the final third. I also fancy Roberto above Casemiro if he plays too.
All and all, I think we can win big and have a good feeling about this one. Neymar looks inspired and unplayable at the moment. Barring an off match or god for bid an injury over the break, I don't see how they could stop him from doing damage, particularly if Ramos isn't fit and can't neutralize Suarez to allow the rest of the back line to focus on Neymar.