If the leaked tactics are true and we're playing a possession-based game against Italy then we could get absolutely schooled. I am not confident at all.
I've seem stats that show that Spain do some of the most running of anyone at major tournament. I don't think possession play uses much less energy, if at all, once you factor in all that pressing.
So Uruguay with or without Suarez to demolish England and the day after tell Liverpool he's leaving because he can't stand to play in such a weak country?