I don't expect Madrid to lose any game other than potentially vs us, they rarely lose to La Liga teams these days. Last two league seasons COMBINED they have lost only 3 games (Atleti away, the Clasico blowout and that miraculous Bilbao win). With Mbappe getting back to his level seems even more unlikely for them to drop points vs random mid table teams.
Best case scenario for us is they get 2 draws (Atleti and another) which means the Clasico will be title defining. Assuming we don't drop any more points of course.