Busquets is best in the space behind the FW and MF line of the opponent - from there he is the GOAT at finding players behind the MF and D line of the opponents.
In this setup that we will probably see, we will instead of Busquets in that line have both FdJ and Pedri. They will offer less options than Busquets alone, and the few times they get the ball, they will mostly be marked, with their back against the goal and with no good option even if they manage to turn.
Busquets will be in the same line as Lenglet and Mingueza, offering no new line, and these two will be his best options to pass to. When they get the ball, they will mostly have Dest or Alba, who will in turn have no good option either. It will be very easy to read, and might prompt some chaotic chance passes, that might lead to something, from there Messi+Dembele+Griezmann might do something, sometimes they do. But this setup is terrible.