We need Messi for this game. It's maybe not a favored option because of his thigh discomfort but it's still the most logical. I mean he even played against Betis a few days after his knee contusion and look how that turned out. He broke the record for most goals in a calendar year. Besides Osasuna can not be taken that lightly. They may be in the relegation zone but they have conceded the 4th least goals in la liga. If anything we might have less trouble in the Real Madrid fixture because both their center backs are missing AND their keeper. I'd say that Messi should play against Osasuna and get subbed off early if we are winning by a comfortable margin.