Cesc was mostly Laporta and the board's signing. Sanchez was a decent signing, I never thought he was that bad. As for Z, it was personal issues and man-management failure rather than sporting reasoning.
No matter who's signing Fàbregas was, Pep did his best to shoehorn him into the side. It was a mistake no matter how you spin it.
I really liked Alexis too, but he never seems to be able to accomplish what Pep sought from him, which was pretty evident from Pep's interaction with him.
Pep's failings with Z was monumental. It was a bust from a sporting side and from a personal side. Everyone knew what kind of person and player he was, but yet it was blatantly apparent that Pep couldn't handle him inside or outside the pitch. Add that to the fee, and you have one of the worst big name transfers in history.
All that aside, Pep has had some stellar transfers, but I really wouldn't blindly rely on him to pick my transfer targets.