Iniesta got out with a knock against Sevilla. And tbf, athletic scored more after he was subbed in. He's not in top shape. Maybe Busquets. But we don't know if he was too tired too.
Messi and Suarez are forwards, and Enrique probably thought they could so something. But they were also dead tired. It showed.
Iniesta still played half the match, and Suárez and Messi the whole match, so if they are too tired why keep playing them, especially the cup already lost?
I'm not saying the rotations were not needed nor I'm denying that players were tired or out of shape, all I'm saying is he risked too much with the rotations he did and we payed the price, he picked the wrong changes as he could have been more conservative instead of trying to be clever... In the match thread people were anticipating the defeat just by looking at that starting lineup!
Now watch him play our best starting lineup on Monday in a exercise of futility... Therefore risking our top players to injuries and tiredness right before the start of the league, the very things he tried to avoid...