This guy made an analysis of how we could play Messi and Griezmann together
https://threadreaderapp.com/thread/1273848268779290626.html
Good analysis. Maybe time will prove we could give Setien a credit to find the right way to utilize Griezmann and Koeman has seen the same in those small sample of games mentioned (I assume as a Barca fan he has watched more or less all our games even with FDJ not playing in most league games after corona break).
Or maybe he has an even better solution. Either way I think Griezmann is a class player who can still offer a lot and the whole team will benefit if we'll find a way to get the best out of his talent.
Another good thing is I think Trincao could also play as an inside forward so maybe a 4-3-3/4-3-1-2 with inside forwards is what we should do.
FDJ/Busi
Pjanić-VDB/Puig
Messi
Ansu/Memphis-Griezmann/Trincao
When Messi would be rested (which he should do more often) we would also have several players who could play in his position.
We wouldn't have a 30+ goal scorer but anyone of the front four has potential to score 15-20 goals. With a better movement around him I think Messi would also come in more goal scoring chances. And Donny could also provide goals from midfield, maybe Pjanić as well.